Results: Among 290 patients, 36 patients developed LID after 48 months follow-up. We used independent tests and logistic regression for analysis of LID risk association. specific binding ratios (SBRs) of the striatal regions from I-123 FP-CIT SPECT images were analyzed. I-123 FP-CIT SPECT images from baseline, 12, 24, and 48 months were analyzed among with clinical factors. Two hundred and ninety PD dopamine replacement drug-naïve patients (age 61.0 ± 9.7, M: F = 195: 95) were enrolled.
Methods: Data were obtained from the Parkinson's Progression Markers Initiative (PPMI) database. We investigated the changes of dopaminergic innervation during the progression of PD in relation to the development of LID.
Since the mechanism of LID is yet unclear, we analyzed serial N-ω-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl) nortropane (I-123 FP-CIT) single photon emission computed tomography (SPECT) images. 2Department of Nuclear Medicine, Seoul National University Bundang Hospital, Seongnam, South Koreaīackground: Levodopa-induced dyskinesia (LID) is a major complication of dopamine replacement drug usage in Parkinson's disease (PD) patients.1Department of Neurology, Bundang Jesaeng General Hospital, Daejin Medical Center, Seongnam, South Korea.Eun Hye Jeong 1, Mun Kyung Sunwoo 1 and Yoo Sung Song 2 *
